5α-Androstan-3α-ol

• Description :

  5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor) . 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms[1].

• CAS Number :

  [7657-50-3]

• Product Name Alternative :

  3α,5α-Androstanol

• UNSPSC :

  12352211

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Constitutive Androstane Receptor; GABA Receptor

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Smiles :

  C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(CCC4)C

• Molecular Formula :

  C19H32O

• Molecular Weight :

  276.46

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Kliewer SA, et al. Orphan nuclear receptors: shifting endocrinology into reverse. Science. 1999 Apr 30;284 (5415) :757-60.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported