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Panaxytriol

CAT: 0804-HY-W709413Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W709413Size:1 Each
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Description
Panaxytriol is an active component of ginseng. Panaxytriol inhibits the nuclear translocation of NF-κB, thereby reducing the production of pro-inflammatory factors (such as TNF-α, IL-1β, IL-6) and nitric oxide (NO) induced by LPS. Panaxytriol upregulates CYP3A4 by activating the nuclear receptor PXR/CAR. Panaxytriol improves motor dysfunction in a mouse model of brain inflammation. Panaxytriol can be used in the research of neurodegenerative diseases (such as Alzheimer's disease)[2].
CAS Number
87005-03-6
UNSPSC
12352211
Target
Constitutive Androstane Receptor; Cytochrome P450; Interleukin Related; NF-κB; Pregnane X Receptor (PXR) ; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CCCCCCC[C@@H](O)[C@H](O)CC#CC#C[C@H](O)C=C
Molecular Formula
C17H26O3
Molecular Weight
278.39
References & Citations
[1]Yan J, et al. Panaxytriol upregulates CYP3A4 expression through the interaction between nuclear regulators and DNA response elements. J Ethnopharmacol. 2023 Jun 28;310:116398.|[2]Hiramatsu G, et al. Panaxytriol Inhibits Lipopolysaccharide-Induced Microglia Activation in Brain Inflammation in Vivo. Biol Pharm Bull. 2021;44 (7) :1024-1028.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP3A4; IL-1; IL-6; NF-κB

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