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GSTO1-IN-3

CAT: 0804-HY-W615446Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W615446Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSTO1-IN-3 is a potent GSTO1-1 inhibitor with an IC50 of 0.11 μM, and shows selectivity over GSTO2-2, GSTA1-1 and GSTP1-1 (IC50 > 100 μM). GSTO1-IN-3 enhances the cytotoxicity of Cisplatin against human breast cancer cells. GSTO1-IN-3 inhibits IL-1β release in mouse bone marrow-derived macrophage (BMDM) cells. GSTO1-IN-3 attenuates inflammation in mice. GSTO1-IN-3 can be used for breast cancer and inflammation research[1].
CAS Number
158890-32-5
UNSPSC
12352005
Hazard Statement
H302-H315-H318-H335
Target
Glutathione S-transferase; Interleukin Related
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(N1CCC(CC1)CC2=CC=CC=C2)CCl
Molecular Formula
C14H18ClNO
Molecular Weight
251.75
Precautions
P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
References & Citations
[1]Xie Y, et al. Development of potent glutathione transferase Omega-1 inhibitors with applications in inflammation and cancer therapy. Eur J Med Chem. 2025 Dec 5;299:118072.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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