Norbixin

• Description:

  Norbixin is a carotenoid that has been found in B. orellana.It binds to PPARγ in a cell-free assay (Ki = 1.15 μM) [1]. Norbixin attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) in a rat model of cardio-metabolic syndrome[2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  PPAR

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C(O)/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(O)=O

• Molecular Formula:

  C24H28O4

• Molecular Weight:

  380.48

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]A, R., Agrawal, N., Kumar, H., et al. Norbixin, an apocarotenoid derivative activates PPARγ in cardiometabolic syndrome: Validation by in silico and in vivo experimental assessment. Life Sci. 209, 69-77 (2018) .|[2]Somacal, S., Quatrin, A., Ruviaro, A.R., et al. Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation. Food Res. Int. 159, 111522 (2022) .|[3]Barcelos, G.R.M., Grotto, D., Serpeloni, J.M., et al. Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. Environ. Mol. Mutagen. 53 (7), 535-541 (2012) .|[4]Fontaine, V., Monteiro, E., M., F., et al. Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease. Aging (Albany N.Y.) 12 (7), 6151-6171 (2020) .

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  542-40-5