24,25-Epoxycholesterol

• Description:

  24,25-Epoxycholesterol is an oxysterol agonist of the liver X receptor that can inhibit the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in liver cells. 24,25-Epoxycholesterol regulates cholesterol metabolism in the liver[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  HMG-CoA Reductase (HMGCR) ; LXR

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Metabolic Disease

• Purity:

  99.80

• Smiles:

  C[C@@]12[C@] (CC[C@]2 ([H]) [C@H] (C) CCC3C (C) (O3) C) ([H]) [C@@]4 ([H]) [C@@] (CC1) ([H]) [C@@]5 (C (C[C@H] (CC5) O) =CC4) C

• Molecular Formula:

  C27H44O2

• Molecular Weight:

  400.64

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Andrew J Brown, et al. 24 (S),25-epoxycholesterol: a messenger for cholesterol homeostasis. Int J Biochem Cell Biol. 2009 Apr;41 (4) :744-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  72542-49-5