Colestolone

CAT: 0804-HY-W414588Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-W414588Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Colestolone is a 15-ketosterol compound and an inhibitor of HMG-CoA reductase. Colestolone can inhibit the activity of cholesteryl ester transfer protein (CETP) in vitro (IC50: 660 μM) . Colestolone is a cholesterol-lowering agent, and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia[1].

CAS Number

50673-97-7

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

CETP; HMG-CoA Reductase (HMGCR)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Endocrinology; Metabolic Disease

Smiles

C[C@@]12C(=C3[C@@]([C@]4(C)[C@@](CC3)(C[C@@H](O)CC4)[H])(CC1)[H])C(=O)C[C@@]2([C@@H](CCCC(C)C)C)[H]

Molecular Formula

C27H44O2

Molecular Weight

400.64

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kim HS, et al. Chemical synthesis of 15-ketosterols and their inhibitions of cholesteryl ester transfer protein. Bioorg Med Chem. 1995 Apr;3 (4) :367-74.

Shipping Conditions

Room temperature

Scientific Category

Reference compound2

Clinical Information

No Development Reported

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