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5-Acetamide-Butenolide

CAT: 0804-HY-W402074Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W402074Size:1 Each
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Description
5-Acetamide-Butenolide (Butenolide) is a mycotoxin with pro-oxidant activity, which is found in Fusarium. 5-Acetamide-Butenolide disrupts the mitochondrial membrane potential in primary neonatal rat cardiomyocytes. 5-Acetamide-Butenolide also induces the production of thiobarbituric acid reactive substances (TBARS) in isolated rat myocardial mitochondria. 5-Acetamide-Butenolide increases the production of reactive oxygen species (ROS), decreases the levels of GSH and reduces the viability of HepG2 cells[1][2][3].
CAS Number
16275-44-8
Product Name Alternative
Butenolide
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
O=C1OC(NC(C)=O)C=C1
Molecular Formula
C6H7NO3
Molecular Weight
141.12
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Yates S G, et al. Mycotoxins produced by Fusarium nivale isolated from tall fescue (Festuca arundinacea Schreb.) [J]. Phytochemistry, 1968, 7 (1) : 139-146.|[2]Wang YM, et al. Effects of Fusarium mycotoxin butenolide on myocardial mitochondria in vitro. Toxicol Mech Methods. 2009 Feb;19 (2) :79-85.|[3]Wang YM, et al. Depletion of intracellular glutathione mediates butenolide-induced cytotoxicity in HepG2 cells. Toxicol Lett. 2006 Jul 14;164 (3) :231-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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