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N'-Isonicotinoylisonicotinohydrazide

CAT: 0804-HY-W354203-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W354203-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N'-Isonicotinoylisonicotinohydrazide (Compound 7, 1,2-Diisonicotinoylhydrazine) is a competitive inhibitor (IC50=5-30 μM) of bacterial heme oxygenase (HO) . N'-Isonicotinoylisonicotinohydrazide inhibits iron release and bacterial iron acquisition. N'-Isonicotinoylisonicotinohydrazide exhibits selective activity against HO enzymes from Pseudomonas aeruginosa and Neisseria meningitidis. N'-Isonicotinoylisonicotinohydrazide is promising for research of multidrug-resistant Gram-negative bacterial infections[1][2].
CAS Number
4329-75-3
Product Name Alternative
1,2-Diisonicotinoylhydrazine
UNSPSC
12352005
Hazard Statement
H228
Target
Bacterial; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Purity
99.55
Smiles
O=C(C1=CC=NC=C1)NNC(C2=CC=NC=C2)=O
Molecular Formula
C12H10N4O2
Molecular Weight
242.23
Precautions
H228
References & Citations
[1]Furci LM, et al. Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. J Med Chem. 2007 Aug 9;50 (16) :3804-13.|[2]Panda SS, et al. Synthesis, computational studies, antimycobacterial and antibacterial properties of pyrazinoic acid-isoniazid hybrid conjugates. RSC Adv. 2019 Jul 1;9 (35) :20450-20462.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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