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Pyrazinoylguanidine

CAT: 0804-HY-W343043Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W343043Size:1 Each
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Description
Pyrazinoylguanidine (PZG) is an analogue of the potassium sparing diuretic, Amiloride. Pyrazinoylguanidine can lower the systolic and diastolic blood pressure of patients with primary hypertension, has a certain effect on reducing heart rate, and does not affect the concentrations of electrolytes such as sodium, potassium, and chloride in the blood serum. Pyrazinoylguanidine can reduce the hyperglycemia and hyperinsulinemia in type 2 diabetes, reduce the levels of triglycerides, cholesterol, and free fatty acids, and reverse the hyperglycemia and hyperlipidemia induced by thiazide diuretics, such as Hydrochlorothiazide (HY-B0252). Pyrazinoylguanidine ican nhibit the reabsorption of urea by the renal tubules, thereby increasing the clearance rate and excretion volume of urea, reducing the serum urea concentration, and minimizing its toxic accumulation[1].
CAS Number
60398-24-5
Product Name Alternative
PZG
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Derivative
Related Pathways
Others
Field of Research
Cardiovascular Disease; Metabolic Disease
Smiles
N=C(N)NC(C1=CN=CC=N1)=O
Molecular Formula
C6H7N5O
Molecular Weight
165.15
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Vesell ES, et al. Studies on pyrazinoylguanidine: a novel antihypertensive, hypoglycemic and lipolytic drug intended for adjunctive use in hypertensive patients with type 2 diabetes mellitus. Toxicology. 2000 Apr 3;144 (1-3) :5-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19274946-01Pyrazinoylguanidine

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