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Octamethylcyclotetrasiloxane

CAT: 0804-HY-W116007-01Size: 25 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W116007-01Size:25 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Octamethylcyclotetrasiloxane promotes the anchorage-independent growth of MCF-10A and MCF-10F cells. Octamethylcyclotetrasiloxane induces DNA damage, inhibits the expression of DNA-repairing protein BRCA1 under long-term and high-concentration exposure. Octamethylcyclotetrasiloxane exhibits intrinsic estrogenic activity[1].
CAS Number
556-67-2
UNSPSC
12352005
Hazard Statement
H226, H361, H410
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Purity
99.86
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1
Molecular Formula
C8H24O4Si4
Molecular Weight
296.62
Precautions
H226, H361, H410
References & Citations
[1]Farasani A, et al., Exposure to cyclic volatile methylsiloxanes (cVMS) causes anchorage-independent growth and reduction of BRCA1 in non-transformed human breast epithelial cells. J Appl Toxicol. 2017 Apr;37 (4) :454-461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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