Products for Research Use Only
RegisterLogin

Murrayafoline A (Standard)

CAT: 0804-HY-W100287RSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W100287RSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Murrayafoline A (Standard) is the analytical standard of Murrayafoline A. This product is intended for research and analytical applications. Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF) -stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056) -induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer[1][2][3][4].
CAS Number
4532-33-6
Target
IKK; Interleukin Related; JNK; NF-κB; p38 MAPK; Reference Standards; Wnt; β-catenin
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Smiles
CC1=CC2=C(C(=C1)OC)NC3=CC=CC=C23
Molecular Formula
C14H13NO
Molecular Weight
211.26
References & Citations
[1]Li CH, et al. Natural carbazole alkaloid murrayafoline A displays potent anti-neuroinflammatory effect by directly targeting transcription factor Sp1 in LPS-induced microglial cells. Bioorg Chem. 2022 Dec;129:106178. |[2]Han JH, et al. Murrayafoline A Induces a G0/G1-Phase Arrest in Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells. Korean J Physiol Pharmacol. 2015 Sep;19 (5) :421-6. |[3]Choi H, et al. Murrayafoline A attenuates the Wnt/beta-catenin pathway by promoting the degradation of intracellular beta-catenin proteins. Biochem Biophys Res Commun. 2010 Jan 1;391 (1) :915-20. |[4]Chidipi B, et al. Enhancement of contraction and L-type Ca (2+) current by murrayafoline-A via protein kinase C in rat ventricular myocytes. Eur J Pharmacol. 2016 Aug 5;784:33-41.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-W100287-01Murrayafoline A
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)
HY-N7948RIsomaltotetraose (Standard)
HY-N7640RDeoxylimonin (Standard)
HY-N7617RToralactone (Standard)
HY-N7541RAntrodin A (Standard)
HY-N6739RBeauvericin (Standard)
HY-N6687RCalcimycin (Standard)
HY-N3373RLoganetin (Standard)

Alternative Products

CatalogName
GTR19228871-01Murrayafoline A
abx098968-01Standard
ST-08004-02Ascorbic Acid Standard + Gallic Acid Standard + TROLOX Standard + BRS Electrolyte
RE21029ARAb Standard A (Standard 0) 20 ml
ST-80004-01Ascorbic Acid Standard + Gallic Acid Standard + TROLOX Standard for biological samples
BA1634-50Pleconaril (Standard)
BA5440-25Thonzylamine (Standard)
BA5196-10Abaloparatide (Standard)
BA5604-100Rolapitant (Standard)
BA5677-50Atosiban (Standard)

Popular Products