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IPrAgCl

CAT: 0804-HY-W047131Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W047131Size:1 Each
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Description
IPrAgCl is an antibacterial agent. IPrAgCl exhibits antiproliferative activity against MCF7 cell line with an IC50 of 30 nM. IPrAgCl has an IC50 of 35 nM against KB cancer cell line. IPrAgCl induces apoptosis in HL60 cell line. IPrAgCl promotes apoptosis-inducing factor translocation from the mitochondrial to the nuclear compartment[1].
CAS Number
873297-19-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Cancer; Infection
Purity
97.0
Smiles
Cl[Ag]=C1N(C=CN1C=2C(=CC=CC2C(C)C)C(C)C)C=3C(=CC=CC3C(C)C)C(C)C
Molecular Formula
C27H36AgClN2
Molecular Weight
531.92
Precautions
H302, H315, H319, H335
References & Citations
[1]Eloy L, et al., Anticancer activity of silver-N-heterocyclic carbene complexes: caspase-independent induction of apoptosis via mitochondrial apoptosis-inducing factor (AIF) . ChemMedChem. 2012 May;7 (5) :805-14.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound2
Clinical Information
No Development Reported

Chemical Information

CID 91992263
CAS Number873297-19-9
PubChem CID91992263
IUPAC Name1,3-bis[2,6-di(propan-2-yl)phenyl]-2H-imidazole;chlorosilver
Molecular FormulaC27H38AgClN2
Molecular Weight533.9
Topological Polar Surface Area6.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Heavy Atom Count31
Formal Charge0
Complexity459
SMILES
CC(C)C1=C(C(=CC=C1)C(C)C)N2CN(C=C2)C3=C(C=CC=C3C(C)C)C(C)C.Cl[Ag]
InChI
InChI=1S/C27H38N2.Ag.ClH/c1-18(2)22-11-9-12-23(19(3)4)26(22)28-15-16-29(17-28)27-24(20(5)6)13-10-14-25(27)21(7)8;;/h9-16,18-21H,17H2,1-8H3;;1H/q;+1;/p-1
InChIKey
YFNYNZOWUDZMFM-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of CID 91992263
CAS: 873297-19-9
CID: 91992263
Formula: C27H38AgClN2
MW: 533.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight533.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass532.17744
Monoisotopic Mass532.17744
Topological Polar Surface Area6.5 Ų
Heavy Atom Count31
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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