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Ompenaclid (Standard)

CAT: 0804-HY-W015828R-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W015828R-01Size:10 mg
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Description
Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy[1][2].
CAS Number
[353-09-3]
UNSPSC
12352211
Target
Apoptosis; Endogenous Metabolite
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(O)CCNC(N)=N
Molecular Formula
C4H9N3O2
Molecular Weight
131.14
References & Citations
[1]Kurth I, et al. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Sci Adv. 2021 Oct 8;7 (41) :eabi7511.|[2]Creisméas A, et, al. TRPC1 and TRPC3 involvement in DMD physiopathology and as potential targets for treatment in complement to rAAV-microdystrophin. 2021 Oct 1;13.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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