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2′-Deoxy-GDP (trisodium)

CAT: 0804-HY-W013111-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W013111-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a hypoxanthine phosphoribosyltransferase (HGPRT) inhibitor with an IC50 of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites[1].
CAS Number
102783-74-4
Product Name Alternative
DGDP (trisodium) ; 2'-Deoxyguanosine-5'-diphosphate (trisodium)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Nucleoside Antimetabolite/Analog; Parasite
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Purity
98.78
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O[C@H]1C[C@H](N(C=N2)C3=C2C(N=C(N)N3)=O)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O
Molecular Formula
C10H12N5Na3O10P2
Molecular Weight
493.15
Precautions
H315, H319, H335
References & Citations
[1]Md Yousuf Ansari, et al. Establishment of correlation between in-silico and in-vitro test analysis against Leishmania HGPRT to inhibitors. Int J Biol Macromol. 2016 Feb:83:78-96.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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