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Scyllo-Inositol (Standard)

CAT: 0804-HY-W010041RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W010041RSize:1 Each
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Description
Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease[1][2][3].
CAS Number
488-59-5
UNSPSC
12352211
Target
Amyloid-β; α-synuclein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1O)O)O)O)O
Molecular Formula
C6H12O6
Molecular Weight
180.16
References & Citations
[1]Ibrahim T, et al. α-Synuclein aggregation, seeding and inhibition by scyllo-inositol. Biochem Biophys Res Commun. 2016 Jan 15;469 (3) :529-34.|[2]Lai AY, et al. scyllo-Inositol promotes robust mutant Huntingtin protein degradation. J Biol Chem. 2014 Feb 7;289 (6) :3666-76.|[3]Choi JK, et al. Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models. Neuropharmacology. 2010 Sep-Oct;59 (4-5) :353-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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