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DGM

CAT: 0804-HY-W005379-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W005379-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DGM is an inhibitor of the TGF-β1/Smad signaling pathway with significant antifibrotic effects. DGM inhibits the epithelial-mesenchymal transition (EMT) process in alveolar epithelial cells and slows the progression of pulmonary fibrosis in vivo by reducing lung inflammation, improving lung function, and decreasing extracellular matrix (ECM) remodeling. DGM can be used in research on idiopathic pulmonary fibrosis (IPF) and EMT-related diseases[1].
CAS Number
162401-62-9
UNSPSC
12352005
Hazard Statement
H301
Target
TGF-beta/Smad
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
Molecular Formula
C12H12F2O4
Molecular Weight
258.22
Precautions
H301
References & Citations
[1]Sun T, et al. Inhibitory Effects of 3-Cyclopropylmethoxy-4- (difluoromethoxy) Benzoic Acid on TGF-β1-Induced Epithelial-Mesenchymal Transformation of In Vitro and Bleomycin-Induced Pulmonary Fibrosis In Vivo. Int J Mol Sci. 2023 Mar 24;24 (7) :6172.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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