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Rabbit Polyclonal Antibody to HEXIM1

CAT: 1725-P23155-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P23155-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869) . In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869) . May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550) . Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728) .
Product Name Alternative
CLP1; EDG1; HIS1; MAQ1
Swiss Prot
O94992
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230
Clonality
Polyclonal
Applications
WB, IHC, IF
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
HEXIM1
Bands Size
Calculated MW: 41 kDa; Observed MW: 41 kDa

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