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RC148

CAT: 0804-HY-P991739Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P991739Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RC148 is a humanized IgG1 silenced bispecific antibody targeting VEGF and PD-1. RC148 allows dimeric VEGF crosslinking and gradually enhances PD-1 binding activity, potentially reduces systemic toxicity of the anti-VEGF approach, and enhances antitumor potency via VEGF-triggered enrichment in tumor areas. RC148 blocks the binding of VEGF to VEGFR and PD-1 to PD-L1, prevents the growth and migration of human umbilical vein endothelial cells, and enables efficient T cell activation. RC148 can be used for the study of breast cancer and lung cancer[1].
UNSPSC
12352005
Target
PD-1/PD-L1; VEGFR
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
References & Citations
[1]Jianmin Fang, et al. RC148, a novel bispecific antibody targeting PD-1 and VEGF for cancer immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts) ; 2024 Apr 5-10; San Diego, CA. Philadelphia (PA) : AACR; Cancer Res 2024;84 (6_Suppl) :Abstract nr 2734.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported

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