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VHB937

CAT: 0804-HY-P991734-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P991734-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research[1].
UNSPSC
12352211
Target
Calcium Channel; Syk; TREM receptor
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.9
References & Citations
[1]Stangel M, et al. VHB937, a TREM2 stabilizing and activating antibody strongly reduces pathology after peripheral administration in a broad range of animal models for neuroinflammation and neurodegeneration (P4-4.004) . Neurology. 2024;102 (7_supplement_1) .
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Isoform
TREM-2

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