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Lpathomab

CAT: 0804-HY-P991310Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P991310Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control[2].
CAS Number
1253114-37-2
Product Name Alternative
LT3015; LT-3000
UNSPSC
12352203
Target
LPL Receptor
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
[Lpathomab]
References & Citations
[1]Visentin B, et al. Abstract# 1247: In vitro and in vivo efficacy of Lpathomab\# 8482; , a monoclonal antibody directed against lysophosphatidic acid (LPA), in ovarian cancer models[J]. Cancer Research, 2009, 69 (9_Supplement) : 1247-1247.|[2]Crack PJ, et al. Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes. J Neuroinflammation. 2014 Feb 27;11:37.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported

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