Products for Research Use Only
RegisterLogin

COVA208

CAT: 0804-HY-P991234Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P991234Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
COVA208 is a bispecific FynomAb (a fusion protein of an antibody and a Fyn SH3-derived binding protein) that targets HER2. COVA208 induces the degradation of HER2, reduces the levels of HER2, HER3, and EGFR, thereby effectively blocking the downstream signaling pathways of HER2, including the HER3-PI3K-AKT and MAPK pathways, and simultaneously inducing apoptosis of tumor cells. COVA208 is promising for research of cancers, such as HER2-positive breast cancer, gastric cancer, and colorectal cancer[1].
UNSPSC
12352203
Target
Akt; EGFR; p38 MAPK; PI3K
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C([A208])[V]
References & Citations
[1]Brack S, et al. A bispecific HER2-targeting FynomAb with superior antitumor activity and novel mode of action. Mol Cancer Ther. 2014 Aug;13 (8) :2030-9.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Isoform
ErbB2/HER2

Alternative Products

CatalogName
T9901A-965-01COVA208
PTX25931Anti-Human CD340/ERBB2/HER2/NEU (COVA208)
HY286376-01Research Grade Anti-Human CD340/ERBB2/HER2/NEU (COVA208)
A136341Anti-CD340/ERBB2/HER2/NEU (COVA208) Biosimilar (Monoclonal, IgG)

Popular Products