DT-2 (acetate)

• Description:

  DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG) . DT-2 inhibits PKG catalyzed phosphorylation (Ki: 12.5 nM) [1].

• UNSPSC:

  12352209

• Target:

  PKG

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Purity:

  98.64

• Smiles:

  O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]3N(CCC3)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C.O=C(O)C

• Molecular Formula:

  C154H287N53O55

• Molecular Weight:

  3761.25

• References & Citations:

  [1]Pinkse MWH, et al. Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. J Biol Chem. 2009 Jun 12;284 (24) :16354-16368.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported