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Cyclomarin monomer-2

CAT: 0804-HY-P11498Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11498Size:1 Each
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Description
Cyclomarin monomer-2 (Compound 10), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-2 binds to the Mtb ClpC1 protein with a KD of 4.0 nM. The MIC of Cyclomarin monomer-2 against the Mtb H37Rv standard strain is 3.1 μM. Cyclomarin monomer-2 can be used as a key intermediate in the development of Homo-BacPROTACs[1].
UNSPSC
12352209
Target
Bacterial; Drug Intermediate
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
CN1C2=C(C(C[C@@H](C(N(C)[C@H]3C[C@H](CO)C)=O)NC([C@@H](NC([C@H](CC(C)C)N(C)C([C@H](C(C)C)NC([C@H]([C@H](OC)C4=CC=CC=C4)NC([C@@H](NC3=O)C)=O)=O)=O)=O)CC#C)=O)=C1)C=CC=C2
Molecular Formula
C49H68N8O9
Molecular Weight
913.11
References & Citations
[1]Junk L, et al. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria. Nat Commun. 2024 Mar 5;15 (1) :2005
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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