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Pentixather

CAT: 0804-HY-P11451Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11451Size:1 Each
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Description
Pentixather is a radiolabeled peptide that can target CXCR4. Pentixather can disrupt the interaction between leukemic cells and the bone marrow microenvironment by targeting the CXCR4/CXCL12 signaling axis, reduce the retention of leukemic cells in the protective bone marrow niche, and thereby enhance the sensitivity of leukemic cells to treatment. Pentixather can be used for the study of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) [1].
CAS Number
1339959-27-1
UNSPSC
12352209
Target
CXCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C(NCC(N[C@@H](C(N([C@@H](C(N[C@H]1CCCNC(N)=N)=O)CCCN)C)=O)CC2=CC=C(O)C=C2)=O)[C@H](CC(C=C3)=CC4=C3C=CC=C4)NC1=O
Molecular Formula
C36H47N9O6
Molecular Weight
701.82
References & Citations
[1]Rahimian S, et al. CXCR4-targeted theranostics in acute leukemia: disrupting leukemic cell-microenvironment interactions with pentixafor and pentixather. Med Oncol. 2025 Aug 4;42 (9) :402.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CXCR4

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