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IRW

CAT: 0804-HY-P11358Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11358Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD) -induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation[1].
CAS Number
159718-10-2
UNSPSC
12352209
Target
Acetyl-CoA Carboxylase; Angiotensin-converting Enzyme (ACE) ; Mitochondrial Metabolism
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)=O)[C@H]([C@@H](C)CC)N
Molecular Formula
C23H35N7O4
Molecular Weight
473.57
References & Citations
[1]Stepheny C. et al. IRW improves diet-induced non-alcoholic fatty liver disease by reducing steatosis associated with increased capacity for oxidative phosphorylation, Journal of Functional Foods, Volume 112, 2024, 105976, ISSN 1756-4646
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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