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NN1213

CAT: 0804-HY-P11245Size: 1 EachDry Ice: NoHazardous: No
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Description
NN1213 (Peptide 21), a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with an EC50 of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 significantly reduces appetite in rat and dog models. NN1213 can be used for antiobesity research[1].
UNSPSC
12352209
Target
Amylin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CO)C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N5[C@@H](CCC5)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@H]7[C@H](O)C)=O)=O)=O)=O)[C@@H](N)CCCCNC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O
Molecular Formula
C198H316N56O63S2
Molecular Weight
4553.10
References & Citations
[1]Dahl K, et al. NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. J Med Chem. 2024 Jul 25;67 (14) :11688-11700. doi: 10.1021/acs.jmedchem.4c00022. Epub 2024 Jul 3. Erratum in: J Med Chem. 2024 Dec 26;67 (24) :22342.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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