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APY-d3

CAT: 0804-HY-P11035Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11035Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APY-d3 is a EphA4-LBD antagonistic peptide with a Kd of 138 nM. APY-d3 is constrained into a bioactive β-hairpin conformation via a head-to-tail disulfide bond. APY-d3 can be used for cancers like gastric and pancreatic cancers and neurodegenerative diseases like amyotrophic lateral sclerosis and Alzheimer’s disease research[1].
UNSPSC
12352209
Target
Ephrin Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Neurological Disease
Smiles
O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CSSC[C@@H](C(O)=O)NC2=O)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CCCNC(NC(CCN)=O)=N)C(N[C@@H](CO)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@H]2CO)=O)=O)=O)=O)=O)=O)=O)[C@H]6N(C(CCN)=O)CCC6
Molecular Formula
C63H86N16O17S2
Molecular Weight
1403.58
References & Citations
[1]Prentiss AM, et al. Constrained β-Hairpins Targeting the EphA4 Ligand Binding Domain. J Med Chem. 2024 Dec 26;67 (24) :22245-22253.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
EphA

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