APY-d3

• Description :

  APY-d3 is a EphA4-LBD antagonistic peptide with a Kd of 138 nM. APY-d3 is constrained into a bioactive β-hairpin conformation via a head-to-tail disulfide bond. APY-d3 can be used for cancers like gastric and pancreatic cancers and neurodegenerative diseases like amyotrophic lateral sclerosis and Alzheimer’s disease research[1].

• UNSPSC :

  12352209

• Target :

  Ephrin Receptor

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer; Neurological Disease

• Smiles :

  O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CSSC[C@@H](C(O)=O)NC2=O)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CCCNC(NC(CCN)=O)=N)C(N[C@@H](CO)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@H]2CO)=O)=O)=O)=O)=O)=O)=O)[C@H]6N(C(CCN)=O)CCC6

• Molecular Formula :

  C63H86N16O17S2

• Molecular Weight :

  1403.58

• References & Citations :

  [1]Prentiss AM, et al. Constrained β-Hairpins Targeting the EphA4 Ligand Binding Domain. J Med Chem. 2024 Dec 26;67 (24) :22245-22253.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  EphA