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LNSMGQD

CAT: 0804-HY-P11017-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P11017-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LNSMGQD is a peptide that targets the adhesion interface of desmoglein DSG1 and DSG3, and interferes with the DSG trans-interaction single peptide (SP) component. LNSMGQD blocks autoantibody-induced loss of DSG trans-interactions by binding to DSGs, inhibiting p38 MAPK activation and keratin filament retraction. LNSMGQD can be used to study autoimmune skin diseases such as pemphigus vulgaris[1].
CAS Number
1152066-26-6
UNSPSC
12352209
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.92
Smiles
O=C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Molecular Formula
C29H49N9O13S
Molecular Weight
763.82
References & Citations
[1]Spindler V, et al. Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering. J Clin Invest. 2013 Feb;123 (2) :800-11.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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CatalogName
TP3696-01LNSMGQD

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