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YVPGP

CAT: 0804-HY-P10992Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10992Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YVPGP is an oligopeptide exacted from Anthopleura anjunae. YVPGP has a significant antitumor activity by mediating PI3K/AKT/mTOR signaling pathway. YVPGP arrests DU-145 cells in the S phase and induces apoptosis via mitochondrial and death receptor pathways (caspase3, 7, 8, 9) . YVPGP effectively inhibits tumor growth in DU-145 xenografts mice model, promising for prostate cancer research[1].
CAS Number
2095286-57-8
UNSPSC
12352209
Target
Akt; Apoptosis; Bcl-2 Family; Caspase; mTOR; PI3K
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(NCC(N2[C@@H](CCC2)C(O)=O)=O)=O)=O)[C@H](CC3=CC=C(C=C3)O)N
Molecular Formula
C26H37N5O7
Molecular Weight
531.60
References & Citations
[1]Li X, et al. Inhibition of Prostate Cancer DU-145 Cells Proliferation by Anthopleura anjunae Oligopeptide (YVPGP) via PI3K/AKT/mTOR Signaling Pathway. Mar Drugs. 2018 Sep 11;16 (9) :325.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Bax; Bcl-xL; Caspase 3; Caspase 7; Caspase 8; Caspase 9

Alternative Products

CatalogName
TP3769-01YVPGP

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