Buccalin

• Description:

  Buccalin is a neuropeptide that colocalizes with small molecule cardioactive peptides in neuronal B15. When exogenously applied to the ARC neuromuscular junction, Buccalin reduces the amplitude of muscle contraction induced by motor neuron firing and acts only presynaptically. Buccalin has no effect on the rate of muscle relaxation and reduces motor neuron-induced ARC excitatory junction potentials without affecting contraction produced by direct acetylcholine action on the muscle[1].

• UNSPSC:

  12352209

• Target:

  Neuropeptide S Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

• Molecular Formula:

  C45H72N12O15S

• Molecular Weight:

  1053.19

• References & Citations:

  [1]Cropper EC, et al. Structure and action of buccalin: a modulatory neuropeptide localized to an identified small cardioactive peptide-containing cholinergic motor neuron of Aplysia californica. Proc Natl Acad Sci U S A. 1988 Aug;85 (16) :6177-81.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [116786-35-7]