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GIP (22-51) human

CAT: 0804-HY-P10972Size: 1 EachDry Ice: NoHazardous: No
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Description
GIP (22-51) human (Glucose-dependent Insulinotropic Peptide (22-51) human) is a potent proatherosclerotic peptide hormone consisting of 30 amino acids. GIP (22-51) human can activate the NF-κB signaling pathway, promote the expression of MMP-8, and induce the expression of proinflammatory and proatherosclerotic proteins. GIP (22-51) human can also increase the level of intracellular free Ca2+ in THP-1-induced macrophages. GIP (22-51) human can be used in the research of atherosclerosis[1].
CAS Number
957470-49-4
Product Name Alternative
Glucose-dependent Insulinotropic Peptide (22-51) (human)
UNSPSC
12352209
Target
Calcium Channel; MMP; NF-κB
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N6[C@@H](CCC6)C(N[C@@H](CCC(N)=O)C(N7[C@@H](CCC7)C(N[C@@H](CCCNC(N)=N)C(NCC(N8[C@@H](CCC8)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
Molecular Formula
C140H226N44O41
Molecular Weight
3181.56
References & Citations
[1]Masaki T, et al. GIP_HUMAN[22-51] is a new proatherogenic peptide identified by native plasma peptidomics. Sci Rep. 2021 Jul 14;11 (1) :14470.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MMP-8

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