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Zolucatetide

CAT: 0804-HY-P10925-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10925-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zolucatetide (FOG-001; I-66) is a potent β-catenin inhibitor with an IC50 of β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer[1].
CAS Number
3044032-95-0
Product Name Alternative
FOG-001; I-66
UNSPSC
12352209
Target
β-catenin
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.31
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC1=CSC2=C1C=CC=C2)C(N[C@@H](CCC(NCCCC[C@H](NC([C@@H](NC([C@H](C)NC(C(C)(C)NC([C@H](CC3=CC=CC(C(O)=O)=C3)NC([C@@H](N4)CC(O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)C6=O)=O)C(N[C@H](C(N)=O)C)=O)=O)[C@H](CC7=CSC=C7)NC([C@@]8(CCN(C(OCCC/C=C/CCC[C@](NC([C@H](CC(C)(C)C)NC([C@H](CC(O)=O)N9)=O)=O)(CCC/C=C\C[C@]%10(CCCN%10C(C)=O)C9=O)C4=O)=O)C8)N6)=O
Molecular Formula
C102H134N18O25S2
Molecular Weight
2076.39
References & Citations
[1]Brian Halbert WHITE, et al. Stapled peptides and methods thereof. WO2022261257A1.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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