CMCoFx1

CAT: 0804-HY-P10860Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-P10860Size:1 Each

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Description

CMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (KD: 900 pM) and inhibitory activity (Ki: 370 pM) for FXIIa. cMCoFx1 can effectively inhibit endogenous clotting pathways, and cMCoFx1 is stable in serum and non-cytotoxic[1].

CAS Number

2853605-24-8

UNSPSC

12352209

Target

Factor Xa

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=C1N2[C@@](CCC2)(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@]3(CSSC[C@@]4(NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@@]5(CSSC[C@@]1(NC(=O)[C@]([C@H](CC)C)(NC(=O)CNC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC6=CC=C(O)C=C6)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@](CSSC[C@@](C(=O)N7[C@](C(=O)NCC(=O)N[C@@H](C)C(=O)N5)(CCC7)[H])(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC3=O)[H])(NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC4=O)[H])[H])[H])[H])[H])[H])[H])[H])[H])[H]

Molecular Formula

C146H232N52O44S6

Molecular Weight

3612.12

References & Citations

[1]Liu W, et al. An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold. J Am Chem Soc. 2021 Nov 10;143 (44) :18481-18489.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

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GTR19069625-01	CMCoFx1

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