Pep4c

CAT: 0804-HY-P1057Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P1057Size:1 Each
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Description
Pep4c is an inactive control peptide for Pep2m (HY-P1058) . Pep4c lacks functional activity to disrupt Protein Interacting with C Kinase 1 (PICK1) -AMPA receptor (GluA2) or N-ethylmaleimide-sensitive factor (NSF) -GluA2 interactions. Pep4c is used as a negative control in experiments to validate the specificity of Pep2m's effects on AMPA receptor trafficking and synaptic plasticity[1][2][3][4][5][6].
CAS Number
[243843-43-8]
UNSPSC
12352209
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCCN)=O)=O)N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C48H91N17O13S
Molecular Weight
1146.41
References & Citations
[1]Noel J, et al. Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron. 1999 Jun;23 (2) :365-76.|[2]Lüthi A, et al. Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 1999 Oct;24 (2) :389-99.|[3]Gallimore AR, et al. Switching On Depression and Potentiation in the Cerebellum. Cell Rep. 2018 Jan 16;22 (3) :722-733. |[4]Cingolani LA, et al. Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins. Neuron. 2008 Jun 12;58 (5) :749-62.|[5]Summa M, et al. Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training. Neuropharmacology. 2011 Dec;61 (8) :1282-90. |[6]Correia SS, et al. Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. Nat Neurosci. 2008 Apr;11 (4) :457-66.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
AMPA Receptor; NMDA Receptor

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