3',4'-Dimethoxyflavone (Standard)

CAT: 0804-HY-N8572RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N8572RSize:1 Each
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Description
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects[1][2][3][4].
CAS Number
[4143-62-8]
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor; PARP; Reactive Oxygen Species (ROS)
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Smiles
O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC=CC=C13
Molecular Formula
C17H14O4
Molecular Weight
282.30
References & Citations
[1]Budzianowski J, et al. Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. Phytochemistry. 2005 May;66 (9) :1033-9.|[2]Fatokun AA, et al. Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos. Br J Pharmacol. 2013 Jul;169 (6) :1263-78.|[3]Lee JE, et al. 3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells. Toxicol Sci. 2000 Dec;58 (2) :235-42.|[4]Kaur K, et al. 3',4'-Dimethoxyflavone and valproic acid promotes the proliferation of human hematopoietic stem cells. Stem Cell Res Ther. 2013 May 24;4 (3) :60.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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