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Tetrahydropiperine

CAT: 0804-HY-N4205-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4205-01Size:10 mg
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Description
Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs, and an activator of the PI3K/Akt/mTOR pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke[1][2][3].
CAS Number
23434-88-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCCCC1)CCCCC2=CC=C(OCO3)C3=C2
Molecular Formula
C17H23NO3
Molecular Weight
289.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Kumar D, et al. Synthesis, characterization, and anti-inflammatory activity of tetrahydropiperine, piperic acid, and tetrahydropiperic acid via down regulation of NF-κB pathway. Cytokine. 2024 Jun;178:156578.|[2]Ren H, et al. Tetrahydropiperine, a natural alkaloid with neuroprotective effects in ischemic stroke. J Chem Neuroanat. 2024 Mar;136:102397.|[3]Koul S, et al. Structure-activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochromeP450 activities. Bioorg Med Chem. 2000 Jan;8 (1) :251-68.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP1

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CatalogName
BUP13818-01TETRAHYDROPIPERINE

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