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Tetramethylcurcumin

CAT: 0804-HY-N2521-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2521-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].
CAS Number
52328-97-9
Product Name Alternative
FLLL31
UNSPSC
12352005
Hazard Statement
H413
Target
Apoptosis; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(C=CC(/C=C/C(C(C)(C)C(/C=C/C2=CC(OC)=C(OC)C=C2)=O)=O)=C1)OC
Molecular Formula
C25H28O6
Molecular Weight
424.49
Precautions
H413
References & Citations
[1]Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010 Mar 15;70 (6) :2445-54.|[2]Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol. 2014 Jul;21 (1) :128-36.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3

Alternative Products

CatalogName
TN2269-01Tetramethylcurcumin

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