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Ginnalin A

CAT: 0804-HY-N17603Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N17603Size:1 Each
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Description
Ginnalin A (Acertannin) is a Nrf2 activator. Ginnalin A shows antiproliferative activity against HCT116, SW480 and SW620 cells with IC50 values of 24.8, 22.0, and 39.7 μM, respectively. Ginnalin A can induce cancer cells S phase arrest. Ginnalin A can activate the p62-Keap1-Nrf2 signaling pathway, significantly upregulate the mRNA and protein expression of Nrf2, HO-1, and NQO1, and promote the transport of Nrf2 from the cytoplasm to the nucleus. Ginnalin A can be used for the research of colon cancer[1].
CAS Number
76746-56-0
Product Name Alternative
Acertannin
UNSPSC
12352005
Target
Heme Oxygenase (HO) ; Keap1-Nrf2; p62
Related Pathways
Autophagy; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O(C(=O)C1=CC(O)=C(O)C(O)=C1)[C@@H]2[C@@H](O)[C@H](O)[C@@H](COC(=O)C3=CC(O)=C(O)C(O)=C3)OC2
Molecular Formula
C20H20O13
Molecular Weight
468.37
References & Citations
[1]Bi W, et al. Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway. Food Funct. 2018 May 23;9 (5) :2809-2819.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HO-1

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