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Pyrrocidine B

CAT: 0804-HY-N16442Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N16442Size:1 Each
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Description
Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC50 of 4.6 μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity[1].
CAS Number
428439-25-2
UNSPSC
12352005
Target
Endogenous Metabolite; Prolyl Endopeptidase (PREP)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
C[C@]1(C[C@@H]2C)[C@](C(C)=C3)([H])[C@]([C@](C([C@](C(N4)=O)([H])C[C@@]4(C5)O)=O)([H])[C@@H]3C=C)([H])[C@@](OC6=CC=C5C=C6)([H])[C@]1([H])[C@H](C2)C
Molecular Formula
C31H39NO4
Molecular Weight
489.65
References & Citations
[1]Shiono Y, et al. A dimeric pyrrocidine from Neonectria ramulariae is an inhibitor of prolyl oligopeptidase[J]. Phytochemistry Letters, 2012, 5 (1) : 91-95.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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