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Candidusin A

CAT: 0804-HY-N16066Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N16066Size:1 Each
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Description
Candidusin A (CHNQD-0803) (Compound 4) is a AMPK activator with a KD of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells) . Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research[1][2].
CAS Number
81474-59-1
Product Name Alternative
CHNQD-0803
UNSPSC
12352005
Target
AMPK; Apoptosis; NF-κB; TNF Receptor
Related Pathways
Apoptosis; Epigenetics; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC1=CC=C(C2=CC(OC)=C3C(OC4=CC(O)=C(C=C43)O)=C2OC)C=C1
Molecular Formula
C20H16O6
Molecular Weight
352.34
References & Citations
[1]Yurchenko A N, et al. Metabolites of the marine fungus Aspergillus candidus KMM 4676 associated with a kuril colonial ascidian[J]. Chemistry of Natural Compounds, 2017, 53 (4) : 747-749.|[2]Chen J, et al. Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis. Mar Life Sci Technol. 2023 Apr 30;5 (2) :196-210.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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