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Geiparvarin

CAT: 0804-HY-N15657Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N15657Size:1 Each
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Description
Geiparvarin is an anticancer agent and an inhibitor of MAO-B (pIC50 = 6.84 μM) . Geiparvarin exerts anti-tumor effects by downregulating COX2 expression and inhibiting angiogenesis. Geiparvarin blocks the cell cycle at the G1 phase and induces apoptosis of cancer cells. Geiparvarin has anti-microtubule activity and destroys the cytoskeleton to exert anti-proliferative effects. Geiparvarin has research significance for lung cancer, leukemia, and breast cancer[1][2][3][4][5].
CAS Number
36413-91-9
UNSPSC
12352005
Target
Apoptosis; Caspase; COX; Microtubule/Tubulin; Monoamine Oxidase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Neuronal Signaling
Field of Research
Cancer
Smiles
C/C(C(OC(C)1C)=CC1=O)=C\COC2=CC=C(C=CC(O3)=O)C3=C2
Molecular Formula
C19H18O5
Molecular Weight
326.34
References & Citations
[1]Giampietro Viola, et al. Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues. Chem Biodivers. 2004 Sep;1 (9) :1265-80.|[2]Bin Wang, et al. Geiparvarin Inhibits the Progression of Osteosarcoma by Down-regulating COX2 Expression. Chem Biodivers. 2004 Sep;1 (9) :1265-80.|[3]C Bocca, et al. Cytoskeleton-interacting activity of geiparvarin, diethylstilbestrol and conjugates. Chem Biol Interact. 2001 Sep 28;137 (3) :285-305.|[4]Angelo Carotti, et al. Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies. Bioorg Med Chem Lett. 2002 Dec 16;12 (24) :3551-5.|[5]Yikai Zhang, et al. Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. Eur J Med Chem. 2012 Jul:53:356-63.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; COX-2; MAO-B

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CatalogName
TN11509-01Geiparvarin

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