Gostatin

CAT: 0804-HY-N15587Size: 1 EachDry Ice: NoHazardous: No

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Description

Gostatin is an inhibitor of aspartate aminotransferase (GOT) . Gostatin is found in Streptomyces sumanensis nov. sp. NK-23. Gostatin has a strong inhibitory effect on pig heart GOT, a weak inhibitory effect on wheat germ GOT and GPT, and no significant effect on glutamate dehydrogenase and glutamine synthetase. The inhibitory mechanism of gostatin is similar to substrate competitive inhibition, and aspartate has a protective effect on its inhibitory effect. Gostatin can be used to study the catalytic mechanism of GOT and its role in nitrogen metabolism[1].

Product Name Alternative

Gostatine

UNSPSC

12352005

Target

Aminotransferases (Transaminases)

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

OC(CC1=C(NCC(C1=O)N)C(O)=O)=O

Molecular Formula

C8H10N2O5

Molecular Weight

214.18

References & Citations

[1]Sawao Murao, et al. New Aspartate Aminotransferase Inhibitor (Gostatin) Produced by Streptomyces sumanensis nov. sp., NK-23. Agricultural and Biological Chemistry, Volume 45, Issue 4, 1 April 1981, Pages 1039–1041.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

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