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Vicanicin

CAT: 0804-HY-N15449Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N15449Size:1 Each
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Description
Vicanicin is a depsidone compound found in lichens. Vicanicin inhibits the expression of Hsp70, regulates the redox-sensitive mechanisms within cells, promotes the increase of reactive oxygen species (ROS) in cancer cells, changes the Bax/Bcl-2 ratio, activates caspase-3, and triggers apoptosis. Vicanicin inhibits cell growth and induces apoptosis in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. Vicanicin is promising for research of prostate cancer[1].
CAS Number
33211-22-2
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; HSP; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1OC2=C(C(C)=C(C(OC)=C2C)Cl)OC3=C1C(C)=C(C(O)=C3C)Cl
Molecular Formula
C18H16Cl2O5
Molecular Weight
383.22
References & Citations
[1]Russo A, et al. Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: role of Hsp70 protein. Chem Biol Interact. 2012 Jan 5;195 (1) :1-10.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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