4,4′-Secalonic acid D

CAT: 0804-HY-N15380Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-N15380Size:1 Each

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Description

4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity[1].

CAS Number

2265910-52-7

UNSPSC

12352005

Target

Apoptosis; Caspase; PARP; Pyroptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

O[C@H]1[C@](C2=C(O)C[C@@H]1C)(C(OC)=O)OC3=C(C4=C(O[C@]5(C(OC)=O)C(C6=O)=C(O)C[C@H](C)[C@H]5O)C6=C(O)C=C4)C=CC(O)=C3C2=O

Molecular Formula

C32H30O14

Molecular Weight

638.57

References & Citations

[1]Zhang MK, et al. Structurally diverse tetrahydroxanthone analogues from Paraconiothyrium sp. AC31 with pyroptosis induction through targeted inhibition of PARP1 in hepatocellular carcinoma cells. Bioorg Chem. 2025 Feb 26;157:108310.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

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4,4′-Secalonic acid D

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