Hyrtiosal

CAT: 0804-HY-N15327Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-N15327Size:1 Each

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Description

Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC50 value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents[1].

CAS Number

138355-07-4

UNSPSC

12352005

Target

HIV; HIV Integrase

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

C[C@]12[C@@](C[C@@](C)([C@H]2C[C@@H](C3=COC=C3)O)C=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC1)C

Molecular Formula

C25H38O3

Molecular Weight

386.57

References & Citations

[1]Du L, et al. Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site. ChemMedChem. 2008 Jan;3 (1) :173-80.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

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