Eupolauridine

CAT: 0804-HY-N15319Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-N15319Size:1 Each

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Description

Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases[1][2].

CAS Number

58786-39-3

Product Name Alternative

Canangine

UNSPSC

12352005

Target

Fungal; Topoisomerase

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

C1(C2=CC=CC=C23)=NC=CC4=C1C3=NC=C4

Molecular Formula

C14H8N2

Molecular Weight

204.23

References & Citations

[1]Khan SI, et al. Antifungal activity of eupolauridine and its action on DNA topoisomerases. Antimicrob Agents Chemother. 2002 Jun;46 (6) :1785-92.|[2]Lavanya M, et al. Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines. Top Curr Chem (Cham) . 2021 Feb 24;379 (2) :13.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Topo I; Topo II

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