Nocarnickelamide B

CAT: 0804-HY-N15301Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N15301Size:1 Each
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Description
Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC50s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch[1].
UNSPSC
12352005
Target
Myosin; ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Smiles
CC(C)C[C@@H](NC(CNC([C@H]1N(C([C@H](N)CC2=CC=CC=C2)=O)C[C@H](O)C1)=O)=O)C(N3C[C@H](O)C[C@H]3C(NCC(O)=O)=O)=O
Molecular Formula
C29H42N6O9
Molecular Weight
618.68
References & Citations
[1]Bui TTM, Ko H, Um S, Jeong H, Kang SW, Kim H, Song DG, Jung SH, Moon K. Discovery of Dual ROCK1/2 Inhibitors from Nocardiopsis sp. under Metal Stress. ACS Chem Biol. 2025 Feb 21;20 (2) :432-441
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ROCK1; ROCK2

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