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Artocarpesin

CAT: 0804-HY-N15272Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N15272Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Artocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA) . Artocarpesin inhibits the production of NO, PGE2 and ROS by inhibiting COX-2 and iNOS expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases[1][2][3].
CAS Number
3162-09-2
UNSPSC
12352005
Target
Bacterial; COX; NO Synthase; p38 MAPK; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C1C=C(C2=C(O)C=C(O)C=C2)OC3=CC(O)=C(C/C=C(C)\C)C(O)=C13
Molecular Formula
C20H18O6
Molecular Weight
354.35
References & Citations
[1]Manuel N G V, et al. Antimicrobial activity of artocarpesin from Artocarpus heterophyllus Lam. against methicillin-resistant Staphylococcus aureus (MRSA) . Journal of Medicinal Plants Research, 2012, 6 (34) : 4879-82.|[2]Fang SC, et al. Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus. J Agric Food Chem. 2008 Jun 25;56 (12) :4463-8.|[3]Kwon H W, et al. Artocarpesin acts on human platelet aggregation through inhibition of cyclic nucleotides and MAPKs. Applied Biological Chemistry, 2022, 65 (1) : 25.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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