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Azaspirene

CAT: 0804-HY-N15264Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N15264Size:1 Each
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Description
Azaspirene ((-) -Azaspirene) is an angiogenesis and Raf-1 activation inhibitor isolated from the fungus Neosartorya sp. Azaspirene inhibits vascular endothelial growth factor (VEGF) -induced human umbilical vein endothelial cell (HUVEC) migration and Raf-1 activation, but has no effect on the activation of kinase insert domain-containing receptor/fetal liver kinase 1 (VEGF receptor 2) [1].
CAS Number
461644-34-8
Product Name Alternative
(-) -Azaspirene
UNSPSC
12352005
Target
Raf; VEGFR
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O[C@@H]1[C@]2(C(N[C@@]1(O)CC3=CC=CC=C3)=O)OC(/C=C/C=C/CC)=C(C2=O)C
Molecular Formula
C21H23NO5
Molecular Weight
369.41
References & Citations
[1]Asami Y, et al. Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation. Cancer Sci. 2008 Sep;99 (9) :1853-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
T202171-01AZASPIRENE

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