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Oximidine III

CAT: 0804-HY-N14903Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N14903Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oximidine III is an anti-tumor antibiotic. Oximidine III can selectively inhibit the growth of 3Y1 in rat fibroblasts with degeneration of various tumor genes. Oximidine III inhibits v-H-ras-3Y1, v-src-3Y1 cells and the normal 3Y1 cells with IC50s (nM) of 14, 4.5 and 140, respectively. Oximidine III stops RAS-or SRC-denatured cells at G1 phase of the cell cycle and increases p21WAF1 expression[1].
CAS Number
664365-72-4
UNSPSC
12352005
Target
Antibiotic; Bacterial
Related Pathways
Anti-infection
Field of Research
Cancer; Infection
Smiles
CO/N=C/C=C\C(N/C=C/C[C@H]1C[C@@]2([H])[C@](/C=C\C=C\C3=CC=CC(O)=C3C(O1)=O)([H])O2)=O
Molecular Formula
C23H24N2O6
Molecular Weight
424.45
References & Citations
[1]Eveline Vriens, et al. Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents. Angew Chem Int Ed Engl. 2023 Aug 21;62 (34) :e202304476.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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